منابع مشابه
Neuroprotective properties of epoetin alfa.
Erythropoietin and its receptor function as primary mediators of the normal physiological response to hypoxia. Erythropoietin is recognized for its central role in erythropoiesis, but studies in which recombinant human erythropoietin (epoetin alfa) is injected directly into ischaemic rodent brain show that erythropoietin also mediates neuroprotection. Abundant expression of the erythropoietin r...
متن کاملBioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple subcutaneous administrations.
AIM To compare the steady-state pharmacokinetics and pharmacodynamics (PK/PD) of two erythropoesis-stimulating agents (ESA), HX575 (Binocrit, Sandoz GmbH, Holzkirchen, Germany), human recombinant epoetin alfa approved as the first biosimilar ESA, and a comparator epoetin alfa, following multiple subcutaneous administrations. METHODS An open, randomized, parallel group study was conducted in 8...
متن کاملEpoetin alfa: future directions and future research.
The Oncologist 2004;9(suppl 5):70-73 www.TheOncologist.com Correspondence: Heinz Ludwig, M.D., Department of Medicine and Medical Oncology, Wilhelminenspital, Montleartstrasse 37, A-1171 Vienna, Austria. Telephone: 43-1-49-150-2101; Fax: 43-1-49-150-2109; e-mail: [email protected] Received August 19, 2004; accepted for publication September 7, 2004. ©AlphaMed Press 1083-7159/2004/$12.00/0...
متن کاملEpoetin Alfa: A Cause of Coronary Artery Thrombosis
Introduction Epoetin alfa is an erythrocyte-stimulating factor. We here present a case of an anemic patient, who was given epogen before a coronary artery bypass (CABG) surgery and developed periprocedural myocardial infarction. To our knowledge, there has been no previous case reported of epogen causing myocardial infarction. Case Presentation 66-year-old female presented with substernal che...
متن کاملCorrection of anemia with epoetin alfa in chronic kidney disease.
BACKGROUND Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency. Recombinant human erythropoietin (epoetin alfa) is indicated for the correction of anemia associated with this condition. However, the optimal level of hemoglobin correction is not defined. METHODS In this open-label trial, we studied 1432 patients with chronic k...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2002
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/17.suppl_1.8